The structural determinants of checkpoint activation

a structural survey of the polish posters

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Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers

Allosteric communication underlies ligand-dependent transcriptional responses mediated by nuclear receptors. While studies have elucidated many of the components involved in this process, the energetic architecture within the receptor protein that mediates allostery remains unknown. Using a sequence-based method designed to detect coevolution of amino acids in a protein, termed the statistical ...

Instability of the Determinants of Birth Intervals in Ahvaz-Iran: A Structural Change Modelling Approach

Birth interval is one of the major determinants of the fertility rate. In this paper structural change approach is used to study the instabilities in the effects of different socio-economic factors on birth intervals of children with respect to couple's years of marriage factor in Ahvaz-Iran. A class of M-fluctuation tests for parameter instability is used and based on these tests different evi...

The many roads to checkpoint activation

Two parallel and concordant activities characterize cell cycle progression. One is associated with preparation for and execution of DNA replication followed by mitosis (" cell cycle "). Cyclins are the motors of the cell cycle, as they activate the respective CDKs and thereby drive the cell through the sequential phases of the cycle. Their antagonists are CKis, which inhibit the CDKs stalling t...

Structural Determinants of Herpesvirus